Dementia and HRT

Back in 2003… 

In the May 28, 2003 issue of The New York Times (online), an article by Denise Grady opened with the following statement: 

Hormone therapy doubled the risk of Alzheimer’s disease and other types of dementia in women who began the treatment at age 65 or older, a large study has found. The finding disappointed many researchers and doctors, who had hoped for the opposite result: that hormone therapy would prevent Alzheimer’s disease. 

This latest study, which was published the same day in The Journal of the American Medical Association, lasted four years and involved 4,532 women at 39 medical centers, One half took placebos, and the other half took Prempro, a combination of estrogen and progestin, the most widely prescribed type of hormone therapy.

In those four years, 40 cases of dementia cropped up in the hormone group, and 21 in the placebo group. These results mean that “for every 10,000 women 65 and older who take hormones, there will be 45 cases of dementia a year, with 23 of them attributable to the hormones.”

 Wyeth, the manufacturer of Prempro, said it would add a new warning label about the increased risk of dementia.

It’s now 2011. Has anyone seen such a warning label? Just curious.

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